The Dr. Marty Makary, professor at Johns Hopkins Universitymember of the National Academy of Medicine, today highlighted the contents of an article published on PubMed.gov and in the Virology Journal signed by him Dr Yamamoto, where, by means of a public letter, he asks them to stop the inoculation of booster doses due to the decrease in immune function detected after eight months in patients with two doses.
Specifically, the letter signed by Dr. Yamamoto refers to information provided by studies published in The Lancet and pointed out that “immune function in vaccinated individuals, eight months after administration of the two doses of the Covid vaccine, was lower than in the unvaccinated”. In addition, he added to his comment the reference to the European Medicines Agency, where he states: “Frequent booster injections could negatively affect the immune response”.
In your message, you refer to the article published in PubMed which can be read here. It was also published in virologyj.biomedcentral.com
The article, signed by El Dr. Jenki Yamamotois entitled: “Adverse effects of vaccines against COVID-19 and measures to prevent them”.
The summary of the article points to that published recently by The Lancet, on the effectiveness of vaccines and in which it was pointed, in turn, “the decrease in immunity of vaccines over time”. “The study showed that immune function in vaccinated people 8 months after receiving two doses of the COVID-19 vaccine was lower than in unvaccinated people,” Yamamoto notes.
It is precisely this part that Dr. Makary pointed out. And he also recalled that “According to the recommendations of the European Medicines Agency, frequent booster injections of COVID-19 could negatively affect the immune response and may not be feasible”.
The study also notes that “decreased immunity may be due to several factors, including N1-methylpseudouridine, spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. These clinical alterations may explain the reported association between COVID-19 vaccination and shingles.”
Suspend additional booster shots
The doctor Kenji Yamamoto proposes in his article that, as a safety measure: “additional booster vaccinations be suspended. In addition, the date of vaccination should be recorded in the clinical history of patients.
He explains in his study that several practical measures have been reported to prevent a decline in immunity: “limiting the use of nonsteroidal anti-inflammatory drugs, of which paracetamol to maintain low body temperature, appropriate use of antibiotics, smoking cessation, stress management, and limiting the use of lipid preparations, including propofl, which can cause perioperative immunosuppression.
The doctor warns in his article that “vaccination against COVID-19 is an important risk factor for infections in critically ill patients”.
Full content of the article
Dear Editor,
The coronavirus disease (COVID-19) pandemic has led to the widespread use of genetic vaccines, including mRNA and viral vector vaccines. Additionally, booster vaccines have been used, but their effectiveness against the highly mutated spike protein of Omicron strains is limited. Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and declining immunity over time. [ 1]. The study showed that immune function in vaccinated people 8 months after receiving two doses of the COVID-19 vaccine was lower than in unvaccinated people. These findings were more pronounced in older adults and people with pre-existing conditions. According to the recommendations of the European Medicines Agency, frequent booster injections of COVID-19 could negatively affect the immune response and may not be feasible. [ 2 ]. Several countries, including Israel, Chile and Sweden, offer the fourth dose only to the elderly and other groups instead of all people [ 3 ].
Decreased immunity is caused by several factors. First, N1-methylpseudouridine is used as a substitute for uracil in the genetic code. The modified protein can induce the activation of regulatory T cells, leading to a decrease in cellular immunity. [ 4 ]. Therefore, spike proteins are not degraded immediately after administration of mRNA vaccines. Spike proteins found in exosomes circulate throughout the body for more than 4 months [ 5 ]. Additionally, in vivo studies have shown that lipid nanoparticles (LNPs) accumulate in the liver, spleen, adrenal glands and ovaries. [ 6 ]and that the mRNA encapsulated in the LNP is highly inflammatory [ 7]. Newly generated antibodies against the spike protein damage cells and tissues that are primed to produce spike proteins [ 8 ]and vascular endothelial cells are damaged by spike proteins in the blood [ 9 ]; this can damage organs of the immune system, such as the adrenal gland. Additionally, antibody-dependent enhancement may occur, in which infection-promoting antibodies attenuate the effect of neutralizing antibodies in preventing infection. [ 10 ]. The original antigenic sin [ 11 ], that is, the residual immune memory of the Wuhan-like vaccine may prevent the vaccine from being sufficiently effective against variant strains. These mechanisms may also be involved in the exacerbation of COVID-19.
Some studies suggest link between COVID-19 vaccines and reactivation of virus that causes shingles [ 12 , 13 ]. This condition is sometimes called vaccine-acquired immunodeficiency syndrome. [ 14]. Since December 2021, in addition to COVID-19, the Cardiovascular Surgery Department of Okamura Memorial Hospital, Shizuoka, Japan (hereinafter referred to as “the institute”) has encountered cases of difficult-to-control infections. For example, there have been several cases of suspected inflammatory infections after open-heart surgery, which could not be controlled even after several weeks of multiple antibiotic use. The patients showed signs of immunosuppression and there were a few deaths. The risk of infection may increase. Various medical algorithms for assessing postoperative prognosis may need to be revised in the future. Adverse events of vaccine administration, such as vaccine-induced immune thrombotic thrombocytopenia (VITT), have so far been covered up by the media due to biased propaganda. The institute finds many cases in which this cause is recognized. These situations came in waves; however, they are not yet resolved despite the measures put in place to screen for antibodies to heparin-induced thrombocytopenia (HIT) in patients admitted to surgery. Four positive cases of HIT antibodies have been confirmed at the institute since the start of vaccination; this frequency of positive cases for HIT antibodies has rarely been observed before. Fatal cases due to VITT have also been reported following the administration of COVID-19 vaccines. [ Se han confirmado cuatro casos positivos de anticuerpos HIT en el instituto desde el inicio de la vacunación; esta frecuencia de casos positivos para anticuerpos HIT rara vez se ha observado antes. También se han informado casos fatales debido a VITT después de la administración de vacunas COVID-19 [ Se han confirmado cuatro casos positivos de anticuerpos HIT en el instituto desde el inicio de la vacunación; esta frecuencia de casos positivos para anticuerpos HIT rara vez se ha observado antes. También se han informado casos fatales debido a VITT después de la administración de vacunas COVID-19 [15 ].
As a safety measure, additional booster injections should be discontinued. In addition, The date of vaccination and the time elapsed since the last vaccination should be recorded in the patient’s clinical history. Due to the lack of knowledge of this group of diseases among doctors and the general public in Japan, the history of vaccination against COVID-19 is often not documented, as in the case of vaccination against influenza. Time since last COVID-19 vaccination may need to be considered when invasive procedures are required. Several practical measures have been reported that can be implemented to prevent a drop in immunity [ 16]. These include limiting the use of nonsteroidal anti-inflammatory drugs, including paracetamolto maintain low body temperature, appropriate use of antibiotics, smoking cessation, stress management, and limiting the use of lipid emulsions, including propofol, which can lead to perioperative immunosuppression. [ 17 ].
To date, when comparing the pros and cons of mRNA vaccines, vaccination has been commonly recommended. As the COVID-19 pandemic is better controlled, the fallout from the vaccine will likely become more apparent. It has been hypothesized that there will be an increase in cardiovascular disease, particularly acute coronary syndromes, caused by spike proteins in genetic vaccines [ 18 , 19]. In addition to the risk of infections due to decreased immune functions, there is a possible risk of unknown organ damage caused by the vaccine which remained hidden without apparent clinical manifestations, mainly in the circulatory system. Therefore, careful risk assessments before surgery and invasive medical procedures are essential. Further randomized controlled trials are needed to confirm these clinical observations.
In conclusion, vaccination against COVID-19 is an important risk factor for infections in critically ill patients.“